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Rapid and Convenient Microwave-Assisted Synthesis of Primary Amines via Reductive N-Alkylation of Methyl Carbamate with Aldehydes

Fredrik Lehmann, Martin Scobie*

*Orexo AB, Virdings Allé 32A, 754 50 Uppsala, Sweden, Email:

F. Lehmann, M. Scobie, Synthesis, 2008, 1679-1681.

DOI: 10.1055/s-2008-1067040


An experimentally simple Microwave-assisted reductive alkylation of methyl carbamate with a range of aldehydes provides, after basic work-up, structurally diverse primary amines. This method is particularly amenable to high-throughput synthesis.

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Key Words

aminations, aldehydes, reductive alkylation, carbamates (deprotection), primary amines, microwave synthesis, silanes

ID: J66-Y2008-1390