The first Bischler-Napieralski cyclization in a room temperature ionic liquid

Zaher M. A. Judeh*, Chi Bun Ching, Jie Bu and Adam McCluskey

*Chemical and Process Engineering Centre, National University of Singapore, 10 Kent Ridge Crescent, Singapore 117576, Email: zaherntu.edu.sg

Z. M. A. Judeh, C. B. Ching, J. Bu, A. McCluskey, Tetrahedron Lett., 2002, 43, 5089-5091.

DOI: 10.1016/S0040-4039(02)00998-X

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Abstract

The room temperature ionic liquid, 1-butyl-3-methylimidazoliumhexafluorophosphate ([bmim]PF₆) is an environmentally benign solvent for the preparation of activated 3,4-dihydroisoquinolines derivatives through Bischler-Napieralski cyclization under mild conditions with excellent purity and yields.

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Key Words

3,4-dihydroisoquinolines, Bischler-Napieralski Reaction, ionic liquids

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ID: J72-Y2002-1810