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A Cu(I)-Catalyzed C-H α-Amination of Esters. Direct Synthesis of Hydantoins

Baoguo Zhao, Haifeng Du and Yian Shi

*Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, Email: yianlamar.colostate.edu

B. Zhao, H. Du, Y. Shi, J. Am. Chem. Soc., 2008, 130, 7220-7221.

DOI: 10.1021/ja802242h


Abstract

A novel intermolecular α-amination process of esters using CuCl as catalyst and di-tert-butyldiaziridinone as nitrogen source forms hydantoins effectively under mild reaction conditions.

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Key Words

Hydantoins


ID: J48-Y2008-1520