Zinc-Catalyzed Synthesis of Pyrazolines and Pyrazoles via Hydrohydrazination
Karolin Alex, Annegret Tillack, Nicolle Schwarz and Matthias Beller
*Leibniz-Institut für Katalyse e.V., Universität Rostock, Albert-Einstein-Str. 29a, 18059 Rostock, Germany, Email: matthias.bellercatalysis.de
K. Alex, A. Tillack, N. Schwarz, M. Beller, Org. Lett., 2008, 10, 2377-2379.
DOI: 10.1021/ol800592s
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Abstract
Arylhydrazines regioselectively react with 3-butynol in the presence of a catalytic amount of zinc triflate to give aryl-substituted pyrazolines. The resulting products are easily oxidized in a one-pot procedure to the corresponding pyrazoles.
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Key Words
ID: J54-Y2008-1530