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Zinc-Catalyzed Synthesis of Pyrazolines and Pyrazoles via Hydrohydrazination

Karolin Alex, Annegret Tillack, Nicolle Schwarz and Matthias Beller

*Leibniz-Institut für Katalyse e.V., Universität Rostock, Albert-Einstein-Str. 29a, 18059 Rostock, Germany, Email:

K. Alex, A. Tillack, N. Schwarz, M. Beller, Org. Lett., 2008, 10, 2377-2379.

DOI: 10.1021/ol800592s (free Supporting Information)

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Arylhydrazines regioselectively react with 3-butynol in the presence of a catalytic amount of zinc triflate to give aryl-substituted pyrazolines. The resulting products are easily oxidized in a one-pot procedure to the corresponding pyrazoles.

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ID: J54-Y2008-1530