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Ozonolysis in Solvent/Water Mixtures: Direct Conversion of Alkenes to Aldehydes and Ketones

Charles E. Schiaffo and Patrick H. Dussault*

*Department of Chemistry, University of Nebraska−Lincoln, Lincoln Nebraska 68588-0304, Email:

C. E. Schiaffo, P. H. Dussault, J. Org. Chem., 2008, 73, 4688-4690.

DOI: 10.1021/jo800323x


Ozonolysis of alkenes in the presence of a small amount of water results in the direct formation of aldehydes and/or ketones, avoiding the need to isolate or decompose ozonides.

see article for more examples

alkene ozonolysis: traditional versus one-step approach

Pyridine Is an Organocatalyst for the Reductive Ozonolysis of Alkenes

R. Willand-Charnley, T. J. Fisher, B. M. Johnson, P. H. Dussault, Org. Lett., 2012, 14, 2242-2245.

Key Words

Ozonolysis, Ozone

ID: J42-Y2008-1580