Efficient Synthetic Method of Multisubstituted Allenes from the Reactions of Allylindium Reagents with 3°-Propargyl Alcohols

Kooyeon Lee and Phil Ho Lee*

*National Research Laboratory for Catalytic Organic Reaction, Department of Chemistry and Institute for Molecular Science & Fusion Technology, Kangwon National University, Chunchon 200-701, Republic of Korea, Email: phleekangwon.ac.kr

K. Lee, P. H. Lee, Org. Lett., 2008, 10, 2441-2444.

DOI: 10.1021/ol800719g

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Abstract

An efficient synthetic method provides tri- and tetra-substituted allenes by the reaction of allylindium reagents with 3°-propargyl alcohols. Allylindium reagents are generated in situ from indium and allyl bromides.

see article for more examples

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Selective Indium-Mediated 1,2,4-Pentatrien-3-ylation of Carbonyl Compounds for the Efficient Synthesis of Vinyl Allenols

J. Park, S. Hong, P. H. Lee, Org. Lett., 2008, 10, 5067-5070.

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Key Words

Allenes, 1,4-Dienes, Indium

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ID: J54-Y2008-1620