The Newman-Kwart rearrangement re-evaluated by microwave synthesis
Jonathan D. Moseley*, Rosalind F. Sankey, Olivier N. Tang and John P. Gilday
*AstraZeneca, Process Research and Development, Avlon Works, Severn Road, Hallen, Bristol BS10 7ZE, UK, Email: jonathan.moseleyastrazeneca.com
J. D. Moseley, R. F. Sankey, O. N. Tang, J. P. Gilday, Tetrahedron, 2006, 62, 4685-4689.
Microwave technology has proven to be ideal for investigating the Newman-Kwart rearrangement (NKR) at high temperatures and facilitated the confirmation of many aspects of this valuable reaction. Comparisons between thermal and microwave results indicate no evidence of a significant microwave effect.
see article for more examples
J. D. Moseley, P. Lenden, Tetrahedron, 2007, 63, 4120-4125.