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Mild, Efficient Friedel-Crafts Acylations from Carboxylic Acids Using Cyanuric Chloride and AlCl3

Cyrous O. Kangani* and Billy W. Day

*Department of Medicine, School of Medicine, and Departments of Pharmaceutical Sciences and of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, Email:

C. O. Kangani, B. W. Day, Org. Lett., 2008, 10, 2645-2648.

DOI: 10.1021/ol800752v


A mild method enables both inter- and intramolecular Friedel-Crafts acylations with aromatic and aliphatic carboxylic acids in high yield and in very short reaction times in the presence of cyanuric chloride, pyridine, and AlCl3 at room temperature.

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Key Words

Friedel-Crafts Acylation, Aryl Ketones

ID: J54-Y2008-1740