Mild, Efficient Friedel-Crafts Acylations from Carboxylic Acids Using Cyanuric Chloride and AlCl3
Cyrous O. Kangani* and Billy W. Day
*Department of Medicine, School of Medicine, and Departments of Pharmaceutical Sciences and of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, Email: cyrouskanganigmail.com
C. O. Kangani, B. W. Day, Org. Lett., 2008, 10, 2645-2648.
DOI: 10.1021/ol800752v (free Supporting Information)
A mild method enables both inter- and intramolecular Friedel-Crafts acylations with aromatic and aliphatic carboxylic acids in high yield and in very short reaction times in the presence of cyanuric chloride, pyridine, and AlCl3 at room temperature.
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