Intramolecular Pd(II)-Catalyzed Oxidative Biaryl Synthesis Under Air: Reaction Development and Scope
Benoît Liégault, Doris Lee, Malcolm P. Huestis, David R. Stuart and Keith Fagnou*
*Center for Catalysis Research and Innovation, Department of
Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, ON, K1N 6J7, Canada, Email:
keith.fagnou
uottawa.ca
B. Liégault, D. Lee, M. P. Huestis, D. R. Stuart, K. Fagnou, J. Org. Chem., 2008, 73, 5022-5028.
DOI: 10.1021/jo800596m
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Abstract
An intramolecular palladium(II)-catalyzed oxidative carbon-carbon bond formation under air in the presence of pivalic acid as the reaction solvent, instead of acetic acid, results in greater reproducibility, higher yields, and broader substrate scope. The reaction allows the conversion of both electron-rich and electron-deficient diarylamines.
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Key Words
Carbazoles, Dibenzofurans, Oxygen
ID: J42-Y2008-1780
