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The Phase-Transfer Catalyzed Ramberg-Bäcklund Reaction

George D. Hartman*, Richard D. Hartman

*Department of Medicinal Chemistry, Merck Research Laboratories, P.O. Box 4, 770 Sumneytown Pike, West Point, Pennsylvania 19486, USA

G. D. Hartman, R. D. Hartman, Synthesis, 1982, 504-506.

DOI: 10.1055/s-1982-29858


α-Halo sulfones readily undergo the Ramberg-Bäcklund rearrangement under phase-transfer conditions to afford olefinic products in excellent yields. An in situ generation of α-halo sulfones in the presence of carbon tetrachloride and subsequent rearrangement is accomplished in a similar manner.

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Key Words

Ramberg-Bäcklund Reaction

ID: J66-Y1982-170