The Phase-Transfer Catalyzed Ramberg-Bäcklund Reaction
George D. Hartman*, Richard D. Hartman
*Department of Medicinal Chemistry, Merck Research Laboratories, P.O. Box 4, 770 Sumneytown Pike, West Point, Pennsylvania 19486, USA
G. D. Hartman, R. D. Hartman, Synthesis, 1982, 504-506.
α-Halo sulfones readily undergo the Ramberg-Bäcklund rearrangement under phase-transfer conditions to afford olefinic products in excellent yields. An in situ generation of α-halo sulfones in the presence of carbon tetrachloride and subsequent rearrangement is accomplished in a similar manner.
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