Synthesis of Styrenes Using Ruthenium-Catalyzed Ring-Closing Enyne Metathesis
Kazuhiro Yoshida*, Yuka Shishikura, Hidetoshi Takahashi and Tsuneo Imamoto*
*Department of Chemistry, Graduate School of Science, Chiba University, Yayoi-cho, Inage-ku, Chiba 263-8522, Japan, Email: kyoshidafaculty.chiba-u.jp, imamotofaculty.chiba-u.jp
K. Yoshida, Y. Shishikura, H. Takahashi, T. Imamoto, Org. Lett., 2008, 10, 2777-2780.
DOI: 10.1021/ol8009573 (free Supporting Information)
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The synthesis of substituted styrenes was achieved by ring-closing enyne metathesis (RCEM)/elimination of enyne substrates 12. The synthetic approach was also effective for a different type of enyne substrate 14, yielding corresponding styrene 15.
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K. Yoshida, S. Horiuchi, N. Iwadate, F. Kawagoe, T. Imamoto, Synlett, 2007, 1561-1562.