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Synthesis of Styrenes Using Ruthenium-Catalyzed Ring-Closing Enyne Metathesis

Kazuhiro Yoshida*, Yuka Shishikura, Hidetoshi Takahashi and Tsuneo Imamoto*

*Department of Chemistry, Graduate School of Science, Chiba University, Yayoi-cho, Inage-ku, Chiba 263-8522, Japan, Email:,

K. Yoshida, Y. Shishikura, H. Takahashi, T. Imamoto, Org. Lett., 2008, 10, 2777-2780.

DOI: 10.1021/ol8009573 (free Supporting Information)

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The synthesis of substituted styrenes was achieved by ring-closing enyne metathesis (RCEM)/elimination of enyne substrates 12. The synthetic approach was also effective for a different type of enyne substrate 14, yielding corresponding styrene 15.

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An Efficient Route to Benzene and Phenol Derivatives via Ring-Closing Olefin Metathesis

K. Yoshida, S. Horiuchi, N. Iwadate, F. Kawagoe, T. Imamoto, Synlett, 2007, 1561-1562.

Key Words

Enyne Metathesis, Cyclization, Styrenes

ID: J54-Y2008-1850