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An Improved System for the Palladium-Catalyzed Borylation of Aryl Halides with Pinacol Borane

Kelvin L. Billingsley and Stephen L. Buchwald*

*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Email:

K. L. Billingsley, S. L. Buchwald, J. Org. Chem., 2008, 73, 5589-5591.

DOI: 10.1021/jo800727s (free Supporting Information)


A highly efficient palladium-catalyzed borylation allows the conversion of aryl and heteroaryl iodides, bromides, and several chlorides containing a variety of functional groups to the corresponding corresponding pinacol boronate esters with an inexpensive and atom-economical boron source, pinacol borane.

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ID: J42-Y2008-1920