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Using Toluates as Simple and Versatile Radical Precursors

Kevin Lam and István E. Markó

*Département de Chimie, Bâtiment Lavoisier, Université catholique de Louvain, Place Louis Pasteur, 1, B-1348 Louvain-la-Neuve, Belgium, Email:

K. Lam, I. E. Markó, Org. Lett., 2008, 10, 2919-2922.

DOI: 10.1021/ol800944p

see article for more reactions


A new, easy and versatile methodology for the deoxygenation of alcohols via the corresponding toluates offers a broad scope using simple and commercially available reagents such as toluolyl chloride and samarium(II) iodide. In addition, this methodology is also useful for radical cyclizations directly from toluate precursors.

see article for more examples


Some benefits of the method:

Kevin Lam, December 22, 2009

Organic electrosynthesis using toluates as simple and versatile radical precursors

K. Lam, I. E. Markó, Chem. Commun., 2009, 95-97.

Key Words

deoxygenations, samarium diiodide

ID: J54-Y2008-1990