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One-Pot Synthesis of 2-Substituted Indoles from 2-Aminobenzyl Phosphonium Salts. A Formal Total Synthesis of Arcyriacyanin A

George A. Kraus and Haitao Guo

*Department of Chemistry, Iowa State University, Ames, Iowa 50011, Email:

G. A. Kraus, H. Guo, Org. Lett., 2008, 10, 3061-3063.

DOI: 10.1021/ol801034x


The reaction of (2-aminobenzyl) triphenylphosphonium bromide with aromatic aldehydes or α,β-unsaturated aldehydes under microwave-assisted conditions allows the synthesis of 2-substituted indoles in high yields in a one-pot reaction.

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Key Words

Indoles, Microwave Synthesis

ID: J54-Y2008-2010