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Ligand-Free Copper-Catalyzed C-S Coupling of Aryl Iodides and Thiols

Elena Sperotto, Gerard P. M. van Klink, Johannes G. de Vries and Gerard van Koten*

*Chemical Biology and Organic Chemistry, Debye Institute for Nanomaterials Science, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands, Email:

E. Sperotto, G. P. M. van Klink, J. G. de Vries, G. van Koten, J. Org. Chem., 2008, 73, 5625-5628.

DOI: 10.1021/jo800491k


An aryl-sulfur bond formation between aryl iodides and thiophenols is catalyzed by a low amount of readily available and ligand-free copper iodide salt. Various diaryl thioethers are synthesized under relatively mild reaction conditions with good chemoselectivity and functional group tolerance.

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Key Words

diaryl sulfides

ID: J42-Y2008-2030