Ligand-Free Copper-Catalyzed C-S Coupling of Aryl Iodides and Thiols
Elena Sperotto, Gerard P. M. van Klink, Johannes G. de Vries and Gerard van Koten*
*Chemical Biology and Organic Chemistry, Debye Institute for
Nanomaterials Science, Faculty of Science, Utrecht University, Padualaan 8, 3584
CH Utrecht, The Netherlands, Email: g.vankoten
uu.nl
E. Sperotto, G. P. M. van Klink, J. G. de Vries, G. van Koten, J. Org. Chem., 2008, 73, 5625-5628.
DOI: 10.1021/jo800491k
Abstract
An aryl-sulfur bond formation between aryl iodides and thiophenols is catalyzed by a low amount of readily available and ligand-free copper iodide salt. Various diaryl thioethers are synthesized under relatively mild reaction conditions with good chemoselectivity and functional group tolerance.
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Key Words
ID: J42-Y2008-2030
