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Copper-Catalyzed Sonogashira-Type Reactions Under Mild Palladium-Free Conditions

Florian Monnier*, François Turtaut, Leslie Duroure and Marc Taillefer*

*École Nationale Supérieure de Chimie de Montpellier, Institut Charles Gerhardt Montpellier, CNRS UMR 5253, Architectures Moléculaires et Matériaux Nanostrucuturs, 8 rue de l'Ecole Normale, 34296 Montpellier, Cedex 05 France, Email:,

F. Monnier, F. Turtaut, L. Duroure, M. Taillefer, Org. Lett., 2008, 10, 3203-3206.

DOI: 10.1021/ol801025u (free Supporting Information)


An inexpensive catalytic system using a readily available copper/ligand combination for the Sonogashira-type cross-coupling of aryl iodides and phenyl- and hexyl-acetylene affords disubstituted alkynes in good yields.

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Key Words

Sonogashira-type Couplings

ID: J54-Y2008-2100