Pd(OAc)₂-Catalyzed Aminocarbonylation of Aryl Iodides with Aromatic or Aliphatic Amines in Water

Pawan J. Tambade, Yogesh P. Patil, Mayur J. Bhanushali, Bhalchandra M. Bhanage*

*Department of Chemistry, Institute of Chemical Technology (Autonomous), University of Mumbai, N. Parekh Marg, Matunga, Mumbai 400019, India, Email: bhalchandra_bhanageyahoo.com

P. J. Tambade, Y. P. Patil, M. J. Bhanushali, B. M. Bhanage, Synthesis, 2008, 2347-2352.

DOI: 10.1055/s-2008-1067160

---

Abstract

An efficient ligand-free protocol for the amincocarbonylation of aryl iodides with aromatic and aliphatic amines afforded the desired amides in excellent yields using a low loading of palladium(II) acetate as catalyst in water under mild operating conditions. The system tolerated a wide variety of hindered and functionalized substrates.

see article for more examples

---

---

Key Words

carbonylation, aminocarbonylation, aryl iodides, amines, amides, palladium, green chemistry, multicomponent reactions

---

ID: J66-Y2008-2140