Pd(OAc)2-Catalyzed Aminocarbonylation of Aryl Iodides with Aromatic or Aliphatic Amines in Water
Pawan J. Tambade, Yogesh P. Patil, Mayur J. Bhanushali, Bhalchandra M. Bhanage*
*Department of Chemistry, Institute of Chemical Technology (Autonomous), University of Mumbai, N. Parekh Marg, Matunga, Mumbai 400019, India, Email: bhalchandra_bhanageyahoo.com
P. J. Tambade, Y. P. Patil, M. J. Bhanushali, B. M. Bhanage, Synthesis, 2008, 2347-2352.
An efficient ligand-free protocol for the amincocarbonylation of aryl iodides with aromatic and aliphatic amines afforded the desired amides in excellent yields using a low loading of palladium(II) acetate as catalyst in water under mild operating conditions. The system tolerated a wide variety of hindered and functionalized substrates.
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