Mild Debenzylation of Aryl Benzyl Ether with BCl3 in the Presence of Pentamethylbenzene as a Non-Lewis-Basic Cation Scavenger
Kentaro Okano, Kei-ichiro Okuyama, Tohru Fukuyama, Hidetoshi Tokuyama*
*Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki, Aoba-ku, Sendai 980-8578, Japan, Email: tokuyamamail.pharm.tohoku.ac.jp
K. Okano, K.-i. Okuyama, T. Fukuyama, H. Tokuyama, Synlett, 2008, 1977-1980.
A chemoselective debenzylation of aryl benzyl ethers proceeds at low temperature with a combination of BCl3 and pentamethylbenzene as a cation scavenger in the presence of various functional groups.
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protecting groups, total synthesis, phenols, debenzylation, aryl benzyl ethers