Direct Acylation of Aryl Bromides with Aldehydes by Palladium Catalysis
Jiwu Ruan, Ourida Saidi, Jonathan A. Iggo and Jianliang Xiao*
*Department of Chemistry, Liverpool Centre for Materials and
Catalysis, University of Liverpool, Liverpool L69 7ZD, U.K., Email: j.xiao
liv.ac.uk
J. Ruan, O. Saidi, J. A. Iggo, J. Xiao, J. Am. Chem. Soc., 2008, 130, 10510-10511.
DOI: 10.1021/ja804351z
Abstract
A direct acylation of aryl bromides with aldehydes involves palladium-amine cooperative catalysis, affording synthetically important alkyl aryl ketones in good yields in a straightforward manner, and broadening the scope of metal-catalyzed coupling reactions.
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proposed reaction pathway
Key Words
ID: J48-Y2008-2160
