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Direct Acylation of Aryl Bromides with Aldehydes by Palladium Catalysis

Jiwu Ruan, Ourida Saidi, Jonathan A. Iggo and Jianliang Xiao*

*Department of Chemistry, Liverpool Centre for Materials and Catalysis, University of Liverpool, Liverpool L69 7ZD, U.K., Email:

J. Ruan, O. Saidi, J. A. Iggo, J. Xiao, J. Am. Chem. Soc., 2008, 130, 10510-10511.

DOI: 10.1021/ja804351z


A direct acylation of aryl bromides with aldehydes involves palladium-amine cooperative catalysis, affording synthetically important alkyl aryl ketones in good yields in a straightforward manner, and broadening the scope of metal-catalyzed coupling reactions.

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proposed reaction pathway

Key Words

Acylation, Heck Reaction

ID: J48-Y2008-2160