Convergent and Rapid Assembly of Substituted 2-Pyridones through Formation of N-Alkenyl Alkynylamides Followed by Gold-Catalyzed Cycloisomerization
Hidetomo Imase, Keiichi Noguchi, Masao Hirano and Ken Tanaka*
*Department of Applied Chemistry, Graduate School of Engineering, and Instrumentation Analysis Center, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184-8588, Japan, Email: tanaka-kcc.tuat.ac.jp
H. Imase, K. Noguchi, M. Hirano, K. Tanaka, Org. Lett., 2008, 10, 3563-3566.
Formation of N-alkenyl alkynylamides by N-acylation of imines with alkynoyl chlorides and the subsequent cationic Au(I)/PPh3-catalyzed cycloisomerization allows a convergent and rapid assembly of substituted 2-pyridones.
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2-pyridones, amides, Ghosez's reagent