Magnesium Nitride as a Convenient Source of Ammonia: Preparation of Primary Amides
Gemma E. Veitch, Katy L. Bridgwood and Steven V. Ley*
*Department of Chemistry, Lensfield Road, University of Cambridge, Cambridge CB2 1EW, U.K., Email: svl1000cam.ac.uk
G. E. Veitch, K. L. Bridgwood, S. V. Ley, Org. Lett., 2008, 10, 3623-3625.
DOI: 10.1021/ol801398z (free Supporting Information)
The use of magnesium nitride as a convenient source of ammonia allows a direct transformation of esters to primary amides. Methyl, ethyl, isopropyl, and tert-butyl esters are converted to the corresponding carboxamides in good yields.
see article for more examples
Chemical Safety: Mg3N2 Hazard, http://cen.acs.org/articles/87/i28/Chemical-Safety-Mg3N2-Hazard.html