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Magnesium Nitride as a Convenient Source of Ammonia: Preparation of Primary Amides

Gemma E. Veitch, Katy L. Bridgwood and Steven V. Ley*

*Department of Chemistry, Lensfield Road, University of Cambridge, Cambridge CB2 1EW, U.K., Email: svl1000cam.ac.uk

G. E. Veitch, K. L. Bridgwood, S. V. Ley, Org. Lett., 2008, 10, 3623-3625.

DOI: 10.1021/ol801398z (free Supporting Information)


Abstract

The use of magnesium nitride as a convenient source of ammonia allows a direct transformation of esters to primary amides. Methyl, ethyl, isopropyl, and tert-butyl esters are converted to the corresponding carboxamides in good yields.

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Note

Chemical Safety: Mg3N2 Hazard, http://cen.acs.org/articles/87/i28/Chemical-Safety-Mg3N2-Hazard.html


Key Words

amides


ID: J54-Y2008-2310