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Catalytic Asymmetric Addition of Alcohols to Imines: Enantioselective Preparation of Chiral N,O-Aminals

Guilong Li, Frank R. Fronczek and Jon C. Antilla*

*Department of Chemistry, University of South Florida, 4202 East Fowler Avenue CHE205A, Tampa, Florida 33620, Email:

G. Li, F. R. Fronczek, J. C. Antilla, J. Am. Chem. Soc., 2008, 130, 12216-12217.

DOI: 10.1021/ja8033334


An enantioselective addition of alcohols to imines proceeds in the presence of a catalytic amount of a chiral phosphoric acid catalyst to give the respective chiral N,O-aminals in excellent yield and enantioselectivity.

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Key Words

Hemiaminal Ethers, Organocatalysis

ID: J48-Y2008-2450