Catalytic Conjugate Addition of Cyanide to Enones: Cooperative Catalysis of Ni(0) and Gd(OTf)3
Yuta Tanaka, Motomu Kanai, Masakatsu Shibasaki*
*Graduate School of Pharmaceutical Sciences, The University
of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, Email: mshibasa
mol.f.u-tokyo.ac.jp
Y. Tanaka, M. Kanai, M. Shibasaki, Synlett, 2008, 2295-2298.
Abstract
Gd(OTf)3 as co-catalyst dramatically accelerated a Ni-catalyzed conjugate addition of cyanide to enones. The substrate scope of the reaction is broad, including cyclic, linear, branched, and aromatic enones. Gadolinium triflate is supposed to facilitate the oxidative addition of Ni(0) to enones, which constitutes a key step in the catalytic cycle.
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synthesis of a Tamiflu precursor
Key Words
cooperative catalysis, conjugate addition, nitriles, nickel, gadolinium
ID: J60-Y2008-2480
