One-Pot Negishi Cross-Coupling Reactions of In Situ Generated Zinc Reagents with Aryl Chlorides, Bromides, and Triflates
Shohei Sase, Milica Jaric, Albrecht Metzger, Vladimir Malakhov and Paul Knochel*
*Department Chemie & Biochemie,
Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, Haus F, 81377
München, Germany, Email: paul.knochel
cup.uni-muenchen.de
S. Sase, M. Jaric, A. Metzger, V. Malakhov, P. Knochel, J. Org. Chem., 2008, 73, 7380-7382.
DOI: 10.1021/jo801063c
Abstract
In situ generated aryl, heteroaryl, alkyl, or benzylic polyfunctional zinc reagents obtained by the addition of zinc and LiCl to the corresponding organic iodides undergo smooth Pd(0)-catalyzed Negishi coupling reactions with aryl bromides, chlorides, and triflates in the presence of PEPPSI as a catalyst to produce crosscoupled products in high yields.
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Key Words
ID: J42-Y2008-2550
