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One-Pot Negishi Cross-Coupling Reactions of In Situ Generated Zinc Reagents with Aryl Chlorides, Bromides, and Triflates

Shohei Sase, Milica Jaric, Albrecht Metzger, Vladimir Malakhov and Paul Knochel*

*Department Chemie & Biochemie, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, Haus F, 81377 München, Germany, Email:

S. Sase, M. Jaric, A. Metzger, V. Malakhov, P. Knochel, J. Org. Chem., 2008, 73, 7380-7382.

DOI: 10.1021/jo801063c


In situ generated aryl, heteroaryl, alkyl, or benzylic polyfunctional zinc reagents obtained by the addition of zinc and LiCl to the corresponding organic iodides undergo smooth Pd(0)-catalyzed Negishi coupling reactions with aryl bromides, chlorides, and triflates in the presence of PEPPSI as a catalyst to produce crosscoupled products in high yields.

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Key Words

Negishi Coupling

ID: J42-Y2008-2550