Palladium-Catalyzed Direct (Hetero)arylation of Ethyl Oxazole-4-carboxylate: An Efficient Access to (Hetero)aryloxazoles
Cécile Verrier, Thibaut Martin, Christophe Hoarau* and Francis Marsais
*Institut de Chimie Organique Fine (IRCOF) associé au CNRS (UMR
6014), INSA et Université de Rouen, BP08 76131 Mont Saint Aignan, France, Email:
christophe.hoarau
insa-rouen.fr
C. Verrier, T. Martin, C. Hoarau, F. Marsais, J. Org. Chem., 2008, 73, 7383-7386.
DOI: 10.1021/jo801093n
Abstract
A straightforward route allows the synthesis of 2-(hetero)arylated and 2,5-di(hetero)arylated oxazoles through regiocontrolled palladium-catalyzed direct (hetero)arylation of ethyl oxazole-4-carboxylate with iodo-, bromo-, and chloro(hetero)aromatics.
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Key Words
Oxazoles, Decarboxylation, Arylation
ID: J42-Y2008-2570
