Organic Chemistry Portal



Palladium-Catalyzed Direct (Hetero)arylation of Ethyl Oxazole-4-carboxylate: An Efficient Access to (Hetero)aryloxazoles

Cécile Verrier, Thibaut Martin, Christophe Hoarau* and Francis Marsais

*Institut de Chimie Organique Fine (IRCOF) associé au CNRS (UMR 6014), INSA et Université de Rouen, BP08 76131 Mont Saint Aignan, France, Email:

C. Verrier, T. Martin, C. Hoarau, F. Marsais, J. Org. Chem., 2008, 73, 7383-7386.

DOI: 10.1021/jo801093n (free Supporting Information)


A straightforward route allows the synthesis of 2-(hetero)arylated and 2,5-di(hetero)arylated oxazoles through regiocontrolled palladium-catalyzed direct (hetero)arylation of ethyl oxazole-4-carboxylate with iodo-, bromo-, and chloro(hetero)aromatics.

see article for more examples

see article for more examples

Key Words

Oxazoles, Decarboxylation, Arylation

ID: J42-Y2008-2570