A Highly Efficient Catalyst-Free Cycloisomerization Approach to Indolizinones
Ikyon Kim*, Jihyun Choi, Sunkyung Lee, Ge Hyeong Lee
*College of Pharmacy, Yonsei University, 162-1 Songdo-dong,
Yeonsu-gu, Incheon 406-840, Republic of Korea, Email: ikyonkim
yonsei.ac.kr
I. Kim, J. Choi, S. Lee, G. H. Lee, Synlett, 2008, 2334-2338.
DOI: 10.1055/s-2008-1078022
Abstract
A highly efficient catalyst-free, thermally induced cycloisomerization allows the synthesis of indolizinones from readily available tertiary propargylic alcohols. In addition, this transformation was found to be further expedited by microwave irradiation.
see article for more examples
Expeditious Synthesis of Highly Substituted Indolizinones via a Palladium-Catalyzed Domino Sequence
I. Kim, K. Kim, Org. Lett., 2010, 12, 2500-2503.
Key Words
indolizinones, catalyst-free, cyclization, 1,2-migration, microwave synthesis
ID: J60-Y2008-2580
