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Palladium-Catalyzed Direct C-2 Arylation of Indoles with Potassium Aryltrifluoroborate Salts

Jinlong Zhao, Yuhong Zhang* and Kai Cheng

*Department of Chemistry, Zhejiang University, Hangzhou 310027, Peoples Republic of China, Email:

J. Zhao, Y. Zhang, K. Cheng, J. Org. Chem., 2008, 73, 7428-7431.

DOI: 10.1021/jo801371w


A mild, Pd(OAc)2-catalyzed regioselective cross-coupling between indoles and potassium aryltrifluoroarylborates gives 2-aryl indoles in moderate yields in the presence of Cu(OAc)2 in acetic acid at room temperature.

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Key Words

Indoles, Arylation, Oxygen

ID: J42-Y2008-2630