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Nickel-Catalyzed Asymmetric Cross-Couplings of Racemic Propargylic Halides with Arylzinc Reagents

Sean W. Smith and Gregory C. Fu*

*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Email:

S. W. Smith, G. C. Fu, J. Am. Chem. Soc., 2008, 130, 12645-12647.

DOI: 10.1021/ja805165y


A catalytic asymmetric Negishi cross-coupling of racemic secondary propargylic halides with arylzinc reagents has been developed using commerically available catalyst components (NiCl2·glyme and pybox as ligand).

see article for more examples

Nickel-Catalyzed Asymmetric Negishi Cross-Couplings of Secondary Allylic Chlorides with Alkylzincs

S. Son, G. C. Fu, J. Am. Chem. Soc., 2008, 130, 2756-2757.

Key Words

Propargylation, Negishi Coupling

ID: J48-Y2008-2650