Nickel-Catalyzed Asymmetric Cross-Couplings of Racemic Propargylic Halides with Arylzinc Reagents
Sean W. Smith and Gregory C. Fu*
*Department of Chemistry, Massachusetts Institute of
Technology, Cambridge, Massachusetts 02139, Email: gcfmit.edu
S. W. Smith, G. C. Fu, J. Am. Chem. Soc., 2008, 130, 12645-12647.
DOI: 10.1021/ja805165y
Abstract
A catalytic asymmetric Negishi cross-coupling of racemic secondary propargylic halides with arylzinc reagents has been developed using commerically available catalyst components (NiCl2·glyme and pybox as ligand).
see article for more examples
Nickel-Catalyzed Asymmetric Negishi Cross-Couplings of Secondary Allylic Chlorides with Alkylzincs
S. Son, G. C. Fu, J. Am. Chem. Soc., 2008, 130, 2756-2757.
Key Words
Propargylation, Negishi Coupling
ID: J48-Y2008-2650