Cross-Coupling of Cyclopropyl- and Cyclobutyltrifluoroborates with Aryl and Heteroaryl Chlorides
Gary A. Molander* and Paul E. Gormisky
*Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, Email: gmolandrsas.upenn.edu
G. A. Molander, P. E. Gormisky, J. Org. Chem., 2008, 73, 7481-7485.
DOI: 10.1021/jo801269m
Abstract
Suitable conditions enable the Suzuki-Miyaura coupling reaction of potassium cyclopropyl- and cyclobutyltrifluoroborates in moderate to excellent yield with electron-rich, electron-poor, and hindered aryl chlorides to give various substituted aryl cyclopropanes and cyclobutanes.
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S. D. Dreher, P. G. Dormer, D. L. Sandrock, G. A. Molander, J. Am. Chem. Soc., 2008, 130, 9257-9259.
Key Words
Cyclopropanes, Cyclobutanes, Arenes, Suzuki Coupling
ID: J42-Y2008-2700