Nonracemic Diarylmethanols From CuH-Catalyzed Hydrosilylation of Diaryl Ketones
Ching-Tien Lee and Bruce H. Lipshutz*
*Department of Chemistry and Biochemistry, University of
California, Santa Barbara, California 93106, Email: lipshutz
chem.ucsb.edu
C.-T. Lee, B. H. Lipshutz, Org. Lett., 2008, 10, 4187-4190.
DOI: 10.1021/ol801590j
Abstract
The use of (R)-(−)-(DTBM-SEGPHOS)CuH effects a highly enantioselective 1,2-hydrosilylation of prochiral diaryl ketones to yield nonracemic diarylmethanols in excellent yields.
see article for more examples
Copper(I) Hydride-Catalyzed Asymmetric Hydrosilylation of Heteroaromatic Ketones
B. H. Lipshutz, A. Lower, K. Noson, Org. Lett., 2002, 4, 4045-4048.
Key Words
Copper Hydride, PMHS, Reduction of Ketones
ID: J54-Y2008-2720
