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One-Pot Synthesis of Benzofurans via Palladium-Catalyzed Enolate Arylation with o-Bromophenols

Christian Eidamshaus and Jason D. Burch*

*Merck Frosst Canada, 16711 Trans Canada Hwy., Kirkland, QC, Canada H9H 3L1, Email:

C. Eidamshaus, J. D. Burch, Org. Lett., 2008, 10, 4211-4214.

DOI: 10.1021/ol801510n (free Supporting Information)


A one-pot synthesis of benzofurans which utilizes a palladium-catalyzed enolate arylation demonstrates broad substrate scope and provides differentially substituted benzofurans in moderate yields. The utility of the method is further demonstrated by the synthesis of the natural product eupomatenoid 6 in three steps.

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Eupomatenoid 6 (CAS: 41744-26-7)

Key Words


ID: J54-Y2008-2750