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Synthesis of Indoles via Domino Reaction of N-Aryl Amides and Ethyl Diazoacetate

Sun-Liang Cui, Jing Wang and Yan-Guang Wang*

*Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. China, Email:

S.-L. Cui, J. Wang, Y.-G. Wang, J. Am. Chem. Soc., 2008, 130, 13526-13527.

DOI: 10.1021/ja805706r


A general and concise synthesis of functionalized indoles via electrophilic activation of N-aryl amides and addition of ethyl diazoacetate to these highly activated amides offers a great potential for the synthesis of biologically active and naturally occurring indole derivatives.

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proposed mechanism

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ID: J48-Y2008-2760