Suzuki-Miyaura Coupling of Aryl Tosylates Catalyzed by an Array of Indolyl Phosphine-Palladium Catalysts

Chau Ming So, Chak Po Lau, Albert S. C. Chan and Fuk Yee Kwong*

*Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong, Email: bcfykinet.polyu.edu.hk

C. M. So, C. P. Lau, A. S. C. Chan, F. Y. Kwong, J. Org. Chem., 2008, 73, 7731-7734.

DOI: 10.1021/jo8014819

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Abstract

A family of indolyl phosphine ligands was applied to Suzuki-Miyaura cross-coupling of aryl tosylates with boronic acids, trifluoroborate salts, and boronate esters. Catalyst loading can be reduced to 0.2 mol % for the coupling of nonactivated aryl tosylates.

see article for more examples

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A General Palladium Catalyst System for Suzuki-Miyaura Coupling of Potassium Aryltrifluoroborates and Aryl Mesylates

W. K. Chow, C. M. So, C. P. Lau, F. Y. Kwong, J. Org. Chem., 2010, 75, 5109-5112.

Easily Accessible and Highly Tunable Indolyl Phosphine Ligands for Suzuki-Miyaura Coupling of Aryl Chlorides

C. M. So, C. P. Lau, F. Y. Kwong, Org. Lett., 2007, 9, 2795-2798.

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Key Words

Suzuki Coupling, Biaryls

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ID: J42-Y2008-2770