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An Efficient Method for the Synthesis of α-Hydroxyalkyl Aryl Ketones

Chengqun Chen, Xinghua Feng, Guozhen Zhang, Qin Zhao, Guosheng Huang*

*State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. of China, Email:

C. Chen, X. Feng, G. Zhang, Q. Zhao, G. Huang, Synthesis, 2008, 3205-3208.

DOI: 10.1055/s-0028-1083149


Oxidation of alkyl aryl ketones in the presence of Oxone, trifluoroacetic anhydride and a catalytic amount of iodobenzene affords α-hydroxyalkyl aryl ketones in good yield. This method provides an effective and economical entry for the α-hydroxylation of ketones.

see article for more examples

An Efficient Method for the α-Acetoxylation of Ketones

J. Sheng, Y. Li, M. Tang, B. Gao, G. Huang, Synthesis, 2007, 1165-1168.

Key Words

α-hydroxy ketones, hydroxylation, Oxone, hypervalent iodine compounds, iodobenzene

ID: J66-Y2008-2780