An Efficient Method for the Synthesis of α-Hydroxyalkyl Aryl Ketones
Chengqun Chen, Xinghua Feng, Guozhen Zhang, Qin Zhao, Guosheng Huang*
*State Key Laboratory of Applied Organic Chemistry, Lanzhou
University, Lanzhou 730000, P. R. of China, Email: hgs2368
163.com
C. Chen, X. Feng, G. Zhang, Q. Zhao, G. Huang, Synthesis, 2008, 3205-3208.
DOI: 10.1055/s-0028-1083149
Abstract
Oxidation of alkyl aryl ketones in the presence of Oxone, trifluoroacetic anhydride and a catalytic amount of iodobenzene affords α-hydroxyalkyl aryl ketones in good yield. This method provides an effective and economical entry for the α-hydroxylation of ketones.
see article for more examples
An Efficient Method for the α-Acetoxylation of Ketones
J. Sheng, Y. Li, M. Tang, B. Gao, G. Huang, Synthesis, 2007, 1165-1168.
Key Words
α-hydroxy ketones, hydroxylation, Oxone, hypervalent iodine compounds, iodobenzene
ID: J66-Y2008-2780
