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Dual Role of Alkynyl Halides in One-Step Synthesis of Alkynyl Epoxides

Alexander Trofimov, Natalia Chernyak and Vladimir Gevorgyan*

*Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607-7061, Email: vladuic.edu

A. Trofimov, N. Chernyak, V. Gevorgyan, J. Am. Chem. Soc., 2008, 130, 13538-13539.

DOI: 10.1021/ja806178r (free Supporting Information)



Abstract

Alkynyl halides serve as a source of Br+ and acetylide ions in an efficient one-step preparation of alkynyl epoxides, important organic building blocks, from readily available starting materials.


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proposed mechanism



Key Words

Alkynylation, Epoxides


ID: J48-Y2008-2790