A Highly Active Catalyst for Pd-Catalyzed Amination Reactions: Cross-Coupling Reactions Using Aryl Mesylates and the Highly Selective Monoarylation of Primary Amines Using Aryl Chlorides
Brett P. Fors, Donald A. Watson, Mark R. Biscoe and Stephen L. Buchwald*
*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Email: sbuchwalmit.edu
B. P. Fors, D. A. Watson, M. R. Biscoe, S. L. Buchwald, J. Am. Chem. Soc., 2008, 130, 13552-13554.
A catalyst system based on a new biarylmonophosphine ligand shows excellent reactivity for C-N cross-coupling reactions. This catalyst system enables the use of aryl mesylates as a coupling partner and permits a highly selective monoarylation of an array of primary aliphatic amines and anilines at low catalyst loadings and with fast reaction times.
see article for more examples
B. P. Fors, P. Krattiger, E. Strieter, S. L. Buchwald, Org. Lett., 2008, 10, 3505-3508.