Facile Synthesis of Bicyclo Orthoesters and Bicyclo Amide Acetals Using α,α-Difluoroalkylamines

Seiko Tange, Tsuyoshi Fukuhara, Shoji Hara*

*Graduate School of Engineering, Hokkaido University, Sapporo 060-8628, Japan, Email: sharaeng.hokudai.ac.jp

S. Tange, T. Fukuhara, S. Hara, Synthesis, 2008, 3219-3222.

DOI: 10.1055/s-0028-1083145

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Abstract

Bicyclo orthoesters and amide acetals were prepared from the corresponding triols or diethanolamines using α,α-difluoroalkylamines. The reactions proceeded under mild conditions.

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proposed mechanism

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Key Words

bicyclo orthoesters, orthoesters, bicyclo amide acetals, α,α-difluoroalkylamines, protecting groups, polymers

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ID: J66-Y2008-2840