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Zirconocene-Mediated Synthesis of Cyclobutabenzenes

José Barluenga*, Jonás Calleja, Mara J. Antón, Luca Álvarez-Rodrigo, Félix Rodríguez and Francisco J. Fañanás

*Instituto Universitario de Química Organometálica “Enrique Moles”, Unidad Asociada al CSIC, Universidad de Oviedo, Julián Clavería 8, 33071 Oviedo, Spain, Email: barluengauniovi.es

J. Barluenga, J. Calleja, M. J. Antón, L. Álvarez-Rodrigo, F. Rodríguez, F. J. Fañanás, Org. Lett., 2008, 10, 4469-4471.

DOI: 10.1021/ol801652h


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Abstract

A new, mild, one-pot zirconium-promoted cross-coupling reaction of aryllithium compounds and alkenyl bromides allows the regio- and diastereoselective synthesis of functionalized cyclobutabenzene derivatives from simple and easily available starting materials.

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Key Words

Benzocyclobutenes


ID: J54-Y2008-2880