Organocatalytic Asymmetric Transferhydrogenation of β-Nitroacrylates: Accessing β²-Amino Acids

Nolwenn J. A. Martin, Xu Chen and Benjamin List*

*Max-Planck-Institut für Kohlenforschung, D-45470 Mülheim an der Ruhr, Germany, Email: listmpi-muelheim.mpg.de

N. J. A. Martin, X. Chen, B. List, J. Am. Chem. Soc., 2008, 130, 13862-13863.

DOI: 10.1021/ja8069852

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Abstract

A highly efficient and enantioselective Hantzsch ester mediated conjugate reduction of β-nitroacrylates is catalyzed by a Jacobsen thiourea catalyst. The reaction is a key step in a new route to optically active β²-amino acids.

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Organocatalytic Asymmetric Transfer Hydrogenation of Nitroolefins

N. J. A. Martin, L. Ozores, B. List, J. Am. Chem. Soc., 2007, 129, 8976-8977.

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Key Words

Organocatalysis, Reduction of Unsaturated Compounds, Hantzsch Ester

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ID: J48-Y2008-2910