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An Improved Protocol for the Pd-Catalyzed α-Arylation of Aldehydes with Aryl Halides

Rubén Martín and Stephen L. Buchwald*

*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Email: sbuchwalmit.edu

R. Martín, S. L. Buchwald, Org. Lett., 2008, 10, 4561-4564.

DOI: 10.1021/ol8017775 (free Supporting Information)


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Abstract

An improved protocol for the Pd-catalyzed α-arylation of aldehydes with aryl halides allows the coupling of an array of substrates including challenging electron-rich aryl bromides and less reactive aryl chlorides. The utility of this method has been demonstrated in a total synthesis of (±)-sporochnol.


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(±)-Sporochnol



Key Words

α-arylation


ID: J54-Y2008-2930