Magnesium Nitride as a Convenient Source of Ammonia: Preparation of Pyrroles

Gemma E. Veitch, Katy L. Bridgwood, Karen Rands-Trevor, Steven V. Ley*

*Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK, Email: svl1000cam.ac.uk

G. E. Veitch, K. L. Bridgwood, K. Rands-Trevor, S. V. Ley, Synlett, 2008, 2597-2600.

DOI: 10.1055/s-0028-1083504

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hazard warning

Abstract

The cyclocondensation of 1,4-dicarbonyl compounds with magnesium nitride as a source of ammonia in methanol allows the synthesis of a diverse array of pyrroles.

see article for more examples

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Note

We would recommend that the procedure is followed exactly and that appropriate safety screens and worker safety protection is used owing to rapid build-up of pressures during the reaction process.

Steven V. Ley, February 16, 2010

Chemical Safety: Mg₃N₂ Hazard, http://cen.acs.org/articles/87/i28/Chemical-Safety-Mg3N2-Hazard.html

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Key Words

pyrroles, Paal-Knorr pyrrole synthesis, heterocycles, ammonia, magnesium nitride, combinatorial chemistry, microwave synthesis

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ID: J60-Y2008-2980