A Three-Step Route to a Tricyclic Steroid Precursor
Douglass F. Taber* and Ritesh B. Sheth
*Department of Chemistry & Biochemistry, University of
Delaware, Newark, Delaware 19716, Email: taberdf
udel.edu
D. F. Taber, R. B. Sheth, J. Org. Chem., 2008, 73, 8030-8032.
DOI: 10.1021/jo801767n
see article for more reactions
Abstract
Wittig reaction of aldehydes with (cyclopropylmethyl)triphenylphosphonium bromide delivered alkenyl cyclopropanes. UV irradiation in the presence of Fe(CO)5 converted these alkenyl cyclopropanes to 2-substituted cyclohexenones. This approach enabled a three-step synthesis of the tricyclic core of estrone methyl ether.
see article for more examples
estrone 3-methyl ether (CAS:
1624-62-0)
While ads financed 62% of the published abstracts in 2024, donations allowed us to publish additional 12%. 26% of the abstracts have been published voluntarly. If you kindly donate, we can publish more freely accessible information and help the chemical community even more:
If you don't like pawalls or a flood of more and more advertising, then you can send a clear signal here!
Key Words
Wittig Reaction, Cyclohexenones
ID: J42-Y2008-3030
