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Multicomponent Domino Cyclization-Oxidative Aromatization on a Bifunctional Pd/C/K-10 Catalyst: An Environmentally Benign Approach toward the Synthesis of Pyridines

Omar De Paolis, Jonathan Baffoe, Shainaz M. Landge, Béla Török*

*Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Blvd. Boston, MA 02125, USA, Email:

O. De Paolis, J. Baffoe, S. M. Landge, B. Török, Synthesis, 2008, 3423-3428.

DOI: 10.1055/s-0028-1083177


A one-pot synthesis of substituted pyridines via a domino cyclization-oxidative aromatization approach is based on the use of a new bifunctional noble metal-solid acid catalyst, Pd/C/K-10 montmorillonite and microwave irradiation. The cyclization readily takes place on the strong solid acid while palladium dehydrogenates the dihydropyridine intermediate.

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Key Words

Pyridines, Hantzsch Pyridine Synthesis, Microwave Synthesis, Multicomponent Reactions, Pd/C/K-10 Montmorillonite, Solid Acid, Bifunctional Catalysis, Green Chemistry

ID: J66-Y2008-3190