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Efficient Negishi Coupling Reactions of Aryl Chlorides Catalyzed by Binuclear and Mononuclear Nickel-N-Heterocyclic Carbene Complexes

Zhenxing Xi, Yongbo Zhou and Wanzhi Chen*

*Department of Chemistry, Zhejiang University, Xixi Campus, Hangzhou 310028, P. R. China, Email:

Z. Xi, Y. Zhou, W. Chen, J. Org. Chem., 2008, 73, 8497-8501.

DOI: 10.1021/jo8018686


Mononuclear and binuclear nickel-NHC complexes supported by heteroarene-functionalized NHC ligands are highly efficient catalysts for the coupling of unactivated aryl chlorides and organozinc reagents, leading to biaryls in good to excellent yields under mild conditions.

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Key Words

Negishi Coupling, Biaryls

ID: J42-Y2008-3260