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Chemoselective Etherification of Benzyl Alcohols Using 2,4,6-Trichloro-1,3,5-triazine and Methanol or Ethanol Catalyzed by Dimethyl Sulfoxide

Lili Sun, Yuping Guo, Guisheng Peng, Chunbao Li*

*Department of Chemistry, College of Science, Tianjin University, 300072 Tianjin, P. R. of China, Email:

L. Sun, Y. Guo, G. Peng, C. Li, Synthesis, 2008, 3487-3488.

DOI: 10.1055/s-0028-1083184

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An efficient method chemoselectively converts benzyl alcohols into their methyl or ethyl ethers in the presence of aliphatic or phenolic hydroxyl groups using 2,4,6-trichloro-1,3,5-triazine (TCT) and dimethyl sulfoxide in methanol or ethanol.

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Key Words

benzyl alcohols, chemoselectivity, ethers, sulfoxide, 2,4,6-trichloro-1,3,5-triazine

ID: J66-Y2008-3290