Synthesis of Five- and Six-Membered-Ring Compounds by Environmentally Friendly Radical Cyclizations Using Kolbe Electrolysis
Frédéric Lebreux, Ferdinando Buzzo, István E. Markó*
*Département de Chimie, Université catholique de Louvain, Place Louis Pasteur 1, 1348 Louvain-la-Neuve, Belgium, Email: istvan.markouclouvain.be
F. Lebreux, F. Buzzo, I. E. Markó, Synlett, 2008, 2815-2820.
DOI: 10.1055/s-0028-1083547 (free Supporting Information)
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Substituted carbocycles, tetrahydrofurans, and tetrahydropyrans can be efficiently obtained from unsaturated carboxylic acids. The methodology involves a Kolbe decarboxylation followed by an intramolecular radical cyclization and a radicalradical cross-coupling process.
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proposed Kolbe decarboxylation-radical cyclization-radical capture