Organic Chemistry Portal



Highly Chemoselective Reductive Amination of Carbonyl Compounds Promoted by InCl3/Et3SiH/MeOH System

On-Yi Lee, Ka-Lun Law, Chun-Yu Ho and Dan Yang*

*Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, People's republic of China, Email:

O.-Y. Lee, K.-L. Law, C.-Y. Ho, D. Yang, J. Org. Chem., 2008, 73, 8829-8837.

DOI: 10.1021/jo8016082


Reductive amination of aldehydes and ketones with the InCl3/Et3SiH/MeOH system is highly chemoselective and can be applied to various cyclic, acyclic, aromatic, and aliphatic amines. Functionalities including ester, hydroxyl, carboxylic acid, and olefin are tolerated.

see article for more examples

Key Words

Reductive Amination, Allylic Amines, Triethylsilane

ID: J42-Y2008-3490