Efficient Iron/Copper Cocatalyzed Alkynylation of Aryl Iodides with Terminal Alkynes
He Huang, Hualiang Jiang, Kaixian Chen and Hong Liu*
*Graduate School, Chinese Academy of Sciences, 555 Zuchongzhi
Road, Shanghai 201203, China, Email: hliu
mail.shcnc.ac.cn
H. Huang, H. Jiang, K. Chen, H. Liu, J. Org. Chem., 2008, 73, 9061-9064.
DOI: 10.1021/jo801942h
Abstract
A highly efficient and practical protocol for the coupling of terminal alkynes with aryl iodides is catalyzed by the inexpensive and environmentally benign combination of Fe/Cu. The versatility, generality, low cost, and environmental friendliness, in combination with exceptionally high reaction rates, render this method particularly attractive for industrial applications.
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ID: J42-Y2008-3510
