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Efficient Iron/Copper Cocatalyzed Alkynylation of Aryl Iodides with Terminal Alkynes

He Huang, Hualiang Jiang, Kaixian Chen and Hong Liu*

*Graduate School, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China, Email: hliumail.shcnc.ac.cn

H. Huang, H. Jiang, K. Chen, H. Liu, J. Org. Chem., 2008, 73, 9061-9064.

DOI: 10.1021/jo801942h (free Supporting Information)


Abstract

A highly efficient and practical protocol for the coupling of terminal alkynes with aryl iodides is catalyzed by the inexpensive and environmentally benign combination of Fe/Cu. The versatility, generality, low cost, and environmental friendliness, in combination with exceptionally high reaction rates, render this method particularly attractive for industrial applications.

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Key Words

Alkynylation


ID: J42-Y2008-3510