Organic Chemistry Portal



Carbonylative Cross-Coupling of ortho-Disubstituted Aryl Iodides. Convenient Synthesis of Sterically Hindered Aryl Ketones

B. Michael O'Keefe, Nicholas Simmons and Stephen F. Martin*

*Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712, Email:

B. M. O'Keefe, N. Simmons, S. F. Martin, Org. Lett., 2008, 10, 5301-5304.

DOI: 10.1021/ol802202j

see article for more reactions


A mild and general protocol for the carbonylative Suzuki-Miyaura cross-coupling of sterically hindered ortho-disubstituted aryl iodides with various aryl boronic acids provides an array of substituted biaryl ketones in good yield. A carbonylative Negishi coupling that utilizes alkynyl nucleophiles is also described.

see article for more examples

Key Words

Aryl Ketones, Multicomponent Reactions

ID: J54-Y2008-3540