Organic Chemistry Portal



Micellar Catalysis of Suzuki-Miyaura Cross-Couplings with Heteroaromatics in Water

Bruce H. Lipshutz* and Alexander R. Abela

*Department of Chemistry & Biochemistry, University of California, Santa Barbara, California 93106, Email:

B. H. Lipshutz, A. R. Abela, Org. Lett., 2008, 10, 5329-5332.

DOI: 10.1021/ol801712e (free Supporting Information)

see article for more reactions


Pd-catalyzed couplings of several (hetero)aromatic halides with (hetero)aromatic boronic acids can be conducted under mild conditions in pure water using commercially available Pd catalysts and PTS, a nanomicelle-forming amphiphile.

see article for more examples

Room-Temperature Suzuki-Miyaura Couplings in Water Facilitated by Nonionic Amphiphiles

B. H. Lipshutz, T. B. Petersen, A. R. Abela, Org. Lett., 2008, 10, 1333-1336.

Key Words

Suzuki Coupling, Heterobiaryls, Green Chemistry

ID: J54-Y2008-3560