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Micellar Catalysis of Suzuki-Miyaura Cross-Couplings with Heteroaromatics in Water

Bruce H. Lipshutz* and Alexander R. Abela

*Department of Chemistry & Biochemistry, University of California, Santa Barbara, California 93106, Email: lipshutzchem.ucsb.edu

B. H. Lipshutz, A. R. Abela, Org. Lett., 2008, 10, 5329-5332.

DOI: 10.1021/ol801712e (free Supporting Information)


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Abstract

Pd-catalyzed couplings of several (hetero)aromatic halides with (hetero)aromatic boronic acids can be conducted under mild conditions in pure water using commercially available Pd catalysts and PTS, a nanomicelle-forming amphiphile.

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Room-Temperature Suzuki-Miyaura Couplings in Water Facilitated by Nonionic Amphiphiles

B. H. Lipshutz, T. B. Petersen, A. R. Abela, Org. Lett., 2008, 10, 1333-1336.


Key Words

Suzuki Coupling, Heterobiaryls, Green Chemistry


ID: J54-Y2008-3560